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Topo Gigio is a famous soft foam mouse with dreamy eyes and a naive personality that was the lead character of a children's puppet show on Italian and Spanish television in the early 1960s.

The character's popularity spread to the world after being featured on The Ed Sullivan Show in the US.

The puppet, created by artist Maria Perego, debuted on Italian television in 1959 voiced by actor Giuseppe "Peppino" Mazzullo and later by Davide Garbolino. It took four people to bring the 10" tall character to life, three to manipulate him and one to create his voice. Unlike traditional hand puppets, Topo Gigio could actually appear to walk on his feet, sing, make subtle hand gestures, and even walk up Ed Sullivan's arm and perch on his shoulder.

"Gigi" is a derivative of Luigi (Louis), so Topo Gigio could be translated as Louie Mouse.